王奎(副教授、硕导)

Email: wangkui@nankai.edu.cn

来源:公用更新发稿时间:2020-05-14 09:37


2005年博士毕业于南开大学,2015, 2018年访问美国宾夕法尼亚大学; 20082012年访问加拿大阿尔伯塔大学。主要从事结构生物信息学、单细胞RNA测序分析,深度学习在生物信息中的应用等方向的研究工作。主持并完成国家自然科学基金青年项目1项,已发表SCI学术论文16篇,其中第一作者或通讯作者6篇。

部分论文列表:

Nguyen AT#, Wang K#, Hu G#, Wang X, Miao Z, Azevedo JA, Suh E, Van Deerlin VM, Choi D, Roeder K, Li M*, Lee EB*.  APOE and TREM2 regulate amyloid-responsive microglia in Alzheimer's disease. Acta Neuropathol. 2020 Aug 25. doi: 10.1007/s00401-020-02200-3.

Li X, Wang K, Lyu Y, Pan H, Zhang J, Stambolian D, Susztak K, Reilly MP, Hu G, Li M. Deep learning enables accurate clustering with batch effect removal in single-cell RNA-seq analysis. Nature Communications. 2020 May 11;11(1):1-4.

Gao J, Wu Z, Hu G, Wang K, Song J, Joachimiak A, Kurgan L. Survey of predictors of propensity for protein production and crystallization with application to predict resolution of crystal structures. Current Protein and Peptide Science. 2018 Feb 1;19(2):200-10.

Hu Y, Lin J, Hu J, Hu G, Wang K, Zhang H, Reilly MP, Li M. PennDiff: detecting differential alternative splicing and transcription by RNA sequencing. Bioinformatics. 2018 Jul 15;34(14):2384-91.

Hu G#, Wang K#, Song J, Uversky VN, Kurgan L. Taxonomic landscape of the dark proteomes: Whole‐proteome scale interplay between structural darkness, intrinsic disorder, and crystallization propensity. Proteomics. 2018 Nov;18(21-22):1800243.

Wu Z, Hu G, Wang K, et al. What are the structural features that drive partitioning of proteins in aqueous two-phase systems?[J]. Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics, 2017, 1865(1): 113-120.

Wang C, Hu G, Wang K, Brylinski M, Xie L, Kurgan L. PDID: database of molecular-level putative protein-drug interactions in the structural human proteome. Bioinformatics 10/2015; DOI:10.1093.

Zheng W, Ruan J, Hu G, Wang K, Hanlon M, Gao J. Analysis of Conformational B-Cell Epitopes in theAntibody-AntigenComplexUsingtheDepthFunctionandtheConvexHull.PLoSOne.2015Aug 5;10(8):e0134835. doi:10.1371.

Hu, G#., Wang, K#., Groedendyk, J#., Barakat, K., Mizianty, M. J., Ruan, J., ... & Kurgan, L*. (2014). Human structural proteome-wide characterization of Cyclosporine A targets. Bioinformatics, 30(24):3561-3566.

Peng, Z., Yan, J., Fan, X., Mizianty, M. J., Xue, B., Wang, K., Hu, G & Kurgan, L. (2014). Exceptionally abundant exceptions: comprehensive characterization of intrinsic disorder in all domains of life. Cellular and Molecular Life Sciences, 1-15.

Gao, J., Hu, G., Wu, Z., Ruan, J., Shen, S., Hanlon, M., & Wang, K*. (2014). Improved Prediction of Protein Crystallization, Purification and Production Propensity Using Hybrid Sequence Representation. Current Bioinformatics, 9(1), 57-64.

Wang, K., Gao, J., Shen, S., Tuszynski, J. A., Ruan, J., & Hu, G*. (2013). An Accurate Method for Prediction of Protein-Ligand Binding Site on Protein Surface Using SVM and Statistical Depth Function. BioMed research international, 2013.

Hu G, Gao J, Wang K*, Mizianty MJ, Ruan J, Kurgan L*., (2012) Finding Protein Targets for Small Biologically Relevant Ligands Across Fold Space Using Inverse Ligand Binding

Predictions. Structure. Nov 7;20(11):1815-22.

Cui W, Wang K, Ruan J, et al.(2012) The Molecular Mechanism of Action of the

CR6261-Azichromycin Combination Found through Computational Analysis[J]. PloS one, 7(5): e37790

WangK,CuiW,HuG,GaoJ,WuZ,QiuX,RuanJ*,FengY,QiZ,ShaoY,TuszynskiJA.(2012) Computable features required to evaluate the efficacy of drugs and a universal algorithm to find optimally effective drug in a drug complex. PLoS One. 7(3):e33709. doi: 10.1371/journal.pone.0033709.

Hu G, Shen S, Wang K*. (2011) On the evolution rate in mammalian mitochondrial genomes. Comput Biol Chem. ;35(3):137-42.

Ruan J, Wang K, Yang J, et al. (2005) Highly accurate and consistent method for prediction of helix and strand content from primary protein sequences[J]. Artificial Intelligence in Medicine, 35(1-2): 19-36.